Hypromellose

Hypromellose carries a safety score of 3/5 and appears in 275 indexed US food products.

Safety score 60.0%

3/5 from FDA SAFFA + CSPI Chemical Cuisine

How common is vs other flagged additives?

Number of indexed products containing each of the most common flagged additives — Hypromellose highlighted.

Indexed products containing each flagged additive. Source: Open Food Facts ingredient lists × FDA SAFFA × CSPI Chemical Cuisine.

Caramel Coloring22612Red 4021595Yellow 518987Carrageenan17853Blue 116643Yellow 613560Sucralose10490Hypromellose275
Indexed products containing each flagged additive. Source: Open Food Facts ingredient lists × FDA SAFFA × CSPI Chemical Cuisine.
Safety Score
3/5

Safety Assessment

Hypromellose has a moderate safety profile (3/5). While approved for use, some studies or consumer advocacy groups have raised questions about certain aspects of this ingredient. Consumers who prefer caution may wish to limit intake.

What the Data Says About

Hypromellose currently appears in 275 products across the OpenFoodFacts catalog we index, which gives a concrete measure of its footprint on US grocery shelves. Our internal safety score of 3/5 synthesizes FDA Substances Added to Food (SAFFA) regulatory status with the Center for Science in the Public Interest (CSPI) Chemical Cuisine classification. These two frameworks capture different questions: regulators ask whether exposure at typical intake is acceptable, while consumer-advocacy groups examine cumulative dietary load and vulnerable-population risk.

Hypromellose serves one or more technical functions in food manufacturing — stabilization, flavor, preservation, or structural role — which explains its presence across multiple product categories in our database. Inspection and outbreak records frequently trace back to control failures around functional additives, whether through batch contamination, undisclosed substitutions, or labeling mismatches that trigger recall classifications by the FDA.

No specific concern flags are attached to Hypromellose in our current data snapshot beyond the regulatory and CSPI classifications above. That does not rule out individual sensitivity reactions, and anyone managing allergies, elimination diets, or chronic conditions should verify with a qualified healthcare professional before relying on population-level ratings.

Safety Profile at a Glance

Regulatory and safety classifications for Hypromellose
Source Classification Year
FDA SAFFA Not listed 2024
CSPI Chemical Cuisine Not rated 2024
PlainFoodSafe Score 3/5 2026
Product footprint 275 products OpenFoodFacts

FDA SAFFA database, CSPI Chemical Cuisine ratings, OpenFoodFacts product index. See methodology.

Products Containing

Showing 50 of 275 products

1 mg melatonin
Natrol
100/100
5-mthf 5 Mg Methylfolate
Thorne
100/100
60 billion probiotic
Physician's Choice
100/100
Acetaminophen
Unknown
100/100
acetaminophen arthritis
Unknown
95/100
Advanced Digestive Enzymes
Thorne
100/100
Advanced Hair + Nail Care
Biosil
100/100
Advil dual action shelf
Unknown
100/100
Akkermansia
Akkermy
100/100
Aleve
Unknown
100/100
Aleve pm
Unknown
85/100
aleve pm
Unknown
100/100
Align Probiotic
Unknown
70/100
Alive! Women's 50+ Complete Multivitamin
Nature's Way
100/100
All Day Focus
Unknown
100/100
Allegra
Allegra
100/100
allegra allergy
Unknown
100/100
Allegra d
Unknown
100/100
Allergy Extra Strength
Benadryl
80/100
allergy relief
Unknown
85/100
allergy relief Aldi
Unknown
95/100
Am-02 Energy+focus
Seed
100/100
Amazing Ashwa
Force Factor
100/100
Amino-9 Essentials Powder
NOW Sports
100/100
Ancient Probiotics Gut Restore
Ancient Nutrition
100/100
Apple Cider Vinegar
Bluebonnet
100/100
Apple cider vinegar
Unknown
85/100
Ascorbyl Palmitate 500 Mg
NOW
100/100
Ashwaganda Root Powder 800 mg
Walmart
100/100
Ashwagandha Extra Strength 1300mg
Spring Valley
100/100
azo yeast plus
Unknown
100/100
B Minus
Seeking Health
100/100
B-100 Complex
Nature Made
100/100
B-complex
1st Phorm
100/100
B-Complex with C
Nature Made
100/100
Base Control Women's Multi Daily Nutrients
HUM
100/100
benadryl
Unknown
95/100
Berberine HCl 1,000mg
LifeSeasons
100/100
berkley cetirizine
Unknown
85/100
Berkley Jensen Extra Strength acetaminophen
Unknown
100/100
Better turmeric
Unknown
100/100
Big 10 Probiotic
OLLY
100/100
Bioactive Men's 50+ One Daily Multi
Vthrive
100/100
Biosteel, high performance sports drink
Biosteel
85/100
Black Cohosh Root (item# 10500, 14690, 10402)
Nature's Way
100/100
Blood Builder
MegaFood
100/100
Boron
Nutricost
100/100
Bromelain 2400 GDU/g 500 mg
Now
100/100
C Extra Strength 1000 Mg
Nature Made
100/100
C-1000
Unknown
100/100

Frequently Asked Questions

Is Hypromellose safe to eat?

Hypromellose has a safety score of 3/5. Always check with a healthcare provider if you have specific dietary concerns.

What products contain Hypromellose?

Hypromellose is found in 275 products in our database, spanning various food categories and brands.

What does Hypromellose do in food?

Hypromellose serves various technical functions in food manufacturing and processing.

Where does this ingredient safety data come from?

Safety data comes from the FDA's SAFFA (Substances Added to Food) database, CSPI (Center for Science in the Public Interest) ratings, and the OpenFoodFacts product database. Product counts reflect items cataloged in OpenFoodFacts.