Enzyme

Enzyme carries a safety score of 3/5 and appears in 3,475 indexed US food products.

Safety score 60.0%

3/5 from FDA SAFFA + CSPI Chemical Cuisine

How common is vs other flagged additives?

Number of indexed products containing each of the most common flagged additives — Enzyme highlighted.

Indexed products containing each flagged additive. Source: Open Food Facts ingredient lists × FDA SAFFA × CSPI Chemical Cuisine.

Caramel Coloring22612Red 4021595Yellow 518987Carrageenan17853Blue 116643Yellow 613560Sucralose10490Enzyme3475
Indexed products containing each flagged additive. Source: Open Food Facts ingredient lists × FDA SAFFA × CSPI Chemical Cuisine.
Safety Score
3/5

Safety Assessment

Enzyme has a moderate safety profile (3/5). While approved for use, some studies or consumer advocacy groups have raised questions about certain aspects of this ingredient. Consumers who prefer caution may wish to limit intake.

What the Data Says About

Enzyme currently appears in 3,475 products across the OpenFoodFacts catalog we index, which gives a concrete measure of its footprint on US grocery shelves. Our internal safety score of 3/5 synthesizes FDA Substances Added to Food (SAFFA) regulatory status with the Center for Science in the Public Interest (CSPI) Chemical Cuisine classification. These two frameworks capture different questions: regulators ask whether exposure at typical intake is acceptable, while consumer-advocacy groups examine cumulative dietary load and vulnerable-population risk.

Enzyme serves one or more technical functions in food manufacturing — stabilization, flavor, preservation, or structural role — which explains its presence across multiple product categories in our database. Inspection and outbreak records frequently trace back to control failures around functional additives, whether through batch contamination, undisclosed substitutions, or labeling mismatches that trigger recall classifications by the FDA.

No specific concern flags are attached to Enzyme in our current data snapshot beyond the regulatory and CSPI classifications above. That does not rule out individual sensitivity reactions, and anyone managing allergies, elimination diets, or chronic conditions should verify with a qualified healthcare professional before relying on population-level ratings.

Safety Profile at a Glance

Regulatory and safety classifications for Enzyme
Source Classification Year
FDA SAFFA Not listed 2024
CSPI Chemical Cuisine Not rated 2024
PlainFoodSafe Score 3/5 2026
Product footprint 3,475 products OpenFoodFacts

FDA SAFFA database, CSPI Chemical Cuisine ratings, OpenFoodFacts product index. See methodology.

Products Containing

Showing 50 of 3,475 products

0% Milkfat Fat Free Small Curd Cottage Cheese
Friendship Dairies Llc
95/100
0% milkfat fat free small curd cottage cheese
Friendship Dairies
95/100
100 Calorie Whole Wheat,One Bun
Ozery Bakery
100/100
100% beef burger
Unknown
50/100
100% Wheat Tortillas
Maya's
100/100
100% While Wheat & Honey
Great Grains Bakery
95/100
100% Whole Wheat & Honey Bread
Great Value
95/100
100% whole wheat flour tortillas soft taco
Fit and Active
100/100
100% whole wheat texas rolls
Unknown
100/100
100% whole wheat with multigrain
Unknown
100/100
12 grain bread
Unknown
100/100
2 Original Pizza Crusts
Great Value
95/100
3 Cheese Macaroni
Taylor
100/100
3 cheese, stuffed pasta shells with ricotta, romano & parmesan cheeses
Unknown
100/100
36 Mini Puff Pastry Squares
Unknown
100/100
4 Almond Croissants
Trader Joe's
100/100
4 cheese blend rising crust pizza
Unknown
100/100
4 Cheese Italian Blend
Land O' Lakes
100/100
4 count cinnamon rolls
Marketside
100/100
4 ct pumpkin muffins
Unknown
95/100
4% Milkfat Small Curd Cottage Cheese
Wegmans
100/100
4-meat sausage, bacon, canadian style bacon & pepperoni pizza, 4-meat
Unknown
55/100
4ct cranberry orange nut muffins
Unknown
75/100
5 Cheese Bread
MOTOR CITY PIZZA CO.
100/100
5 cheese bread
Motor City Pizza Co.
100/100
5 Cheese Breadsticks
Marketside
100/100
5 cheese durum flour dough with ricotta, mozzarella, pecorino romano, asiago & parmesan cheeses in a delicious marinara sauce lasagna
Unknown
100/100
5 Cheese Egg Bites
Burnbrae Farms
95/100
5 cheese pizza
Unknown
100/100
5 cheese thin crust pizza
Lucia's
100/100
5 grain baguette crisps
Meijer
100/100
5 meat stuffed crust pizza
Unknown
55/100
505 Southwestern Hatch Kitchen Chicken & Cheese Quesadillas
Unknown
100/100
6 cheese pizza
Unknown
100/100
6 Submarine Rolls
Felix Roma Bakery
85/100
6" famous original cannoli pie
Unknown
100/100
6-inch flour torttilla
Unknown
100/100
6.25 Oz pizza meal
Banquet
55/100
7 layer bean dip
Unknown
100/100
7-eleven fresh to go, chocolate chunk cookie
7-Eleven, 7-Eleven Inc.
100/100
7-eleven fresh to go, oatmeal raisin cookie
7-Eleven, 7-Eleven Inc.
100/100
7-eleven, fresh togo holiday sugar cookie
7-Eleven, 7-Eleven Inc.
0/100
7-eleven, sugar cookie
7-Eleven, 7-Eleven Inc.
50/100
8 Sliced Sandwich Rolls
J.J. Cassone Bakery Inc.
85/100
8" italian sub buns
Unknown
75/100
8" Flour Tortillas
Prayers
100/100
8" Whole Wheat Tortillas
USDA,Tortilla King
100/100
8-inch flour tortilla
Unknown
85/100
8-inch whole wheat tortilla
Unknown
100/100
9 Count Pumpernickle & Rye Roll
Albertsons
100/100

Frequently Asked Questions

Is Enzyme safe to eat?

Enzyme has a safety score of 3/5. Always check with a healthcare provider if you have specific dietary concerns.

What products contain Enzyme?

Enzyme is found in 3,475 products in our database, spanning various food categories and brands.

What does Enzyme do in food?

Enzyme serves various technical functions in food manufacturing and processing.

Where does this ingredient safety data come from?

Safety data comes from the FDA's SAFFA (Substances Added to Food) database, CSPI (Center for Science in the Public Interest) ratings, and the OpenFoodFacts product database. Product counts reflect items cataloged in OpenFoodFacts.